Communication between the microbial diversity in the respiratory tract of pigs and the response to experimental and commercial vaccines against Mycoplasma hyopneumoniae

• Grant number: 23/15067-5
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: April 01, 2024
• End date: March 31, 2025
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Luís Guilherme de Oliveira
• Grantee: Fernando Antônio Moreira Petri
• Supervisor: Marina Sibila Vidal
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Institution abroad: Centre de Recerca en Sanitat Animal (CReSA), Spain
• Associated to the scholarship: 21/14515-9 - Development of an injectable vaccine to control Mycoplasma hyopneumoniae in pigs using SBA-15 nanostructured silica as an adjuvant, BP.DD

Abstract

Swine production in Brazil has evolved to meet global market demands and enhances competitiveness in animal protein production. However, intensified production brings challenges, including respiratory diseases like Porcine Enzootic Pneumonia (PEP), associated with Mycoplasma (M.) hyopneumoniae infection, leading to significant losses. Current commercial vaccines reduce lung lesions but do not prevent pathogen colonization and shedding. The use of mesoporous silica SBA-15 as a carrier-adjuvant shows promising results in improving vaccine efficacy and swine immune response. This technology has the potential to offer better protection against PEP, benefiting swine health and productivity. The internship time includes an experimental trial previously proposed to FAPESP (Process No. 21/14515-9), microbioma and bioinformatic analysis, and its relationship with efficacy using silica-based vaccine in pigs. This study aims to unravel the impact of vaccination on the bacterial diversity of the respiratory tract, providing valuable information for PEP control. Successful results could bridge research gaps, informing future projects targeting vaccination effects via SBA-15 on nasal and lung microbiota. Additionally, the internship will foster studies on pathogenesis, animal model establishment, respiratory pathogen control tools and bioinformatics training. Finally, collaborative discussions with international research groups will explore microbiome analysis application in Brazilian pig production vaccination strategies, with knowledge dissemination to FCAV-Unesp.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PETRI, FERNANDO ANTONIO MOREIRA; MALCHER, CLARISSE SENA; MECHLER-DREIBI, MARINA LOPES; PANNEITZ, ANA KAROLINA; BRAGA, EDUARDA RIBEIRO; DE AGUIAR, GABRIEL ALEXANDRE; TOLEDO, LEONARDO TEOFILO; MARTINS, TEREZA SILVA; CIDES-DA-SILVA, LUIS CARLOS; FANTINI, MARCIA C. A.; et al. Shedding reduction and immunity modulation in piglets with an inactivated Mycoplasma hyopneumoniae vaccine encapsulated in nanostructured SBA-15 silica. Vaccine, v. 42, n. 24, p. 12-pg., 2024-08-28. (21/11914-0, 21/14515-9, 19/08582-5, 23/15067-5, 19/07007-7, 17/17844-8)