Analysis of the circulating metabolomic profile of pregnant women with pre-eclampsia

• Grant number: 23/08897-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: January 01, 2024
• End date: January 31, 2028
• Field of knowledge: Health Sciences - Medicine - Maternal and Child Health
• Principal Investigator: Valeria Cristina Sandrim
• Grantee: Julyane Natsumi Saito Kaihara
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Preeclampsia (PE) is a gestational hypertensive disease characterized by hypertension and end-organ damage. It accounts for complicating 2-8% of pregnancies worldwide and impacts maternal-fetal health. PE can be classified into various subtypes, considering aspects such as onset of symptoms, severity degrees, and responsiveness to antihypertensive therapy - and some are associated with worse clinical outcomes. Metabolomics is the science of metabolites, which comprises compounds involved in several cellular processes and that may indicate phenotypic changes manifested by patients with PE. However, metabolome of pregnant women diagnosed with PE studies from the perspective of responsiveness to antihypertensive therapy is unprecedented. Thus, the objective of the proposed research project is to compare the circulating metabolomic profile in different subtypes of pregnant women with PE using bioinformatics tools with univariate and chemometric analyses. Subsequently, the effects of differential metabolites on human umbilical vein endothelial cell (HUVECs) lineage will be evaluated in terms of cell viability, oxidative stress, and endothelial dysfunction. Therefore, this study may contribute to understanding PE pathophysiology, investigation of future pharmacological targets and potential biomarkers for personalized treatments and better maternal-fetal prognosis.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PINTO-SOUZA, CAROLINE C.; KAIHARA, JULYANE N. S.; NUNES, PRISCILA R.; MASTELLA, MOISES H.; ROSSINI, BRUNO C.; CAVECCI-MENDONCA, BRUNA; CAVALLI, RICARDO DE CARVALHO; DOS SANTOS, LUCILENE D.; SANDRIM, VALERIA C.. Different Proteomic Profiles Regarding Antihypertensive Therapy in Preeclampsia Pregnant. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 16, p. 16-pg., 2024-08-01. (22/07605-4, 23/11925-7, 21/12010-7, 23/08897-1)

KAIHARA, JULYANE N. S.; DE MORAES, FABIO ROGERIO; NUNES, PRISCILA REZECK; ALVES, MARCO G.; CAVALLI, RICARDO C.; TASIC, LJUBICA; SANDRIM, VALERIA CRISTINA. Plasma metabolic profile reveals signatures of maternal health during gestational hypertension and preeclampsia without and with severe features. PLoS One, v. 19, n. 11, p. 22-pg., 2024-11-26. (23/08897-1, 18/24069-3, 19/07230-8, 21/12010-7)