Development of PLLA Polymeric Films Enriched with Muña Oil for Medical Applications: A Sustainable Approach Using the Airbrushing Technique

• Grant number: 23/17544-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2024
• End date: August 31, 2025
• Field of knowledge: Engineering - Chemical Engineering - Chemical Process Industries
• Principal Investigator: Viktor Oswaldo Cardenas Concha
• Grantee: Marcella Chaves Giannoni
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

The use of poly (L-lactic acid) (PLLA) and Muña oil (MO) in the manufacture of biopolymeric films with bioactives has shown promise for medical applications. This is because PLLA is a synthetic polymer widely recognized for its biodegradable properties, low toxicity, and biological compatibility. By combining PLLA with Muña oil, it is possible to obtain polymeric films with notable biological properties. Muña oil has gained notoriety for its antimicrobial, antifungal, anti-inflammatory, and antioxidant properties. These biopolymeric films (PLLA + Muña oil) can be used in a variety of medical applications, opening new horizons for the treatment and prevention of skin diseases. To overcome the challenges in the production of these films, the airbrushing technique will be explored, as this technique is a simple procedure, recognized for its sustainability (lower energy consumption) and respect for the environment. Thus, airbrushing sprays the polymeric solutions in thin streams, forming fibers (micro and nano) as the solvent evaporates. This provides precise control over the thickness and uniformity of the films, resulting in significant improvements in properties such as breathability and moisture absorption. In this project, the aim is to develop biopolymeric films of PLLA enriched with Muña oil, using airbrushing. The optimization of the operating conditions will take into account the PLLA-acetone solution, the air pressure in the airbrush, and the distance between the airbrush and the collection surface, the best concentration of Muña oil incorporation for biological responses will also be evaluated. The resulting films will be analyzed through a series of analyses to characterize the thermal (TGA and DSC), morphological (FTIR, XRD, SEM), mechanical, and biological (in vitro cytotoxicity) properties, controlled release, and antioxidant activity. The purpose of this project is to foster the development of natural and sustainable products with a wide range of applications.