PRO-TUMORAL EFFECT OF BETA-ADRENERGIC RECEPTOR ACTIVATION AND ITS RELATIONSHIP TO THE SIRTUINS PATHWAY AND MODULATION BY EXERCISE MIMETIC

• Grant number: 23/17631-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2024
• End date: December 31, 2025
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Patricia Chakur Brum
• Grantee: Gabriel Albanese Kafouri
• Host Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 24/23586-5 - Effectiveness of cancer therapies targeting Sirtuins: is it dependent on Heme Oxygenase-1 modulation?, BE.EP.IC

Abstract

Studies over the last two decades have shown that chronic stress, through the activation of beta-adrenergic receptors by effector molecules of the Sympathetic Nervous System, plays an important role in the development and progression of cancer; however, the molecular bases underlying these effects require further investigation. On the other hand, it is known that sirtuins, a family of histone deacetylase proteins, are fundamental to the process of tumorigenesis, a fact evidenced by their abnormal pattern of expression in many types of cancer. At the same time, it is well documented in the scientific literature that aerobic physical exercise has an anti-tumor effect and that this effect is possibly mediated by modulating the expression of sirtuins. Thus, this research project aims to investigate the role of sirtuins in inducing the pro-tumor effects of beta-adrenergic stimulation in colorectal cancer cells and to assess whether a mimetic agent of aerobic exercise can attenuate these effects by regulating sirtuins activity.