Synthesis of 1-D-Glucal Amides Derived from 1-Iodo-D-Glucal Through Carbonylative Coupling Reaction

• Grant number: 24/04288-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2024
• End date: May 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Helio Alexandre Stefani
• Grantee: Pamela Moniz Silva
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The project focuses primarily on the use of 1-D-iodoglucal in transformations involving carbonylative coupling reactions with a focus on obtaining new amidoglucals. It is also intended, when possible, to evaluate the biological activity of the prepared compounds (e.g., antifungal, anticancer, and anti-inflammatory activity).