EFFECTS OF AMINOPHYLLINE, CAFFEINE AND DOXAPRAM IN HYPOXIC NEONATAL DOGS BORN BY CESAREAN SECTION

• Grant number: 23/17018-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2024
• End date: March 31, 2026
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Maria Lucia Gomes Lourenço
• Grantee: Júlia Cosenza Mendonça
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Hypoxia is considered the main consequence of perinatal asphyxia and the cause of more than 60% of newborn losses of the canine species in the first days of life. It is related to several factors that cause asphyxia, including obstetric conditions, dystocia, prolonged labor, and anesthetics used during cesarean section, which can influence the initiation and maintenance of spontaneous breathing. Effective respiratory assistance in neonatal resuscitation must be performed with the aim of maintaining airway patency, reducing acidemia, improving respiratory distress, and maintaining adequate tissue oxygen perfusion. The study aims to determine the effects of administering the drugs aminophylline, caffeine and doxapram as respiratory support in hypoxic neonates, evaluating the Apgar score, lactate concentrations, blood glucose, O2 saturation, blood gas analysis and cardiac troponin I. evaluated 40 dogs born by cesarean section, diagnosed with hypoxia at birth. Of these, 10 animals will receive aminophylline - Aminophylline Group (GA), 10 animals will receive caffeine - Caffeine Group (GCaf), 10 animals will receive doxapram (GD), and 10 will be placed in the control group (CG), the latter consisting of neonates who do not require respiratory assistance. Neonates will be assessed at birth and after 10 minutes of respiratory assistance. The study is expected to demonstrate the effectiveness of methylxanthines or doxapram in treating hypoxic newborn dogs. The study will benefit the clinical management of these patients, impacting better care in the immediate postpartum period and the survival rate of newborn dogs.