Synthesis, characterization and in vitro anticancer activity of 1,3,4-Oxadiazoles derived from semicarbazones from vanillin.

• Grant number: 24/03554-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2024
• End date: April 30, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: José Clayston Melo Pereira
• Grantee: Luiz Henrique Salmeron Sigoli
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Cancer is the general name for more than 100 diseases that are seen as a public health problem due to their social, epidemiological and economic magnitude. Cancer, in addition to worsening the patient's physical health, contributes to the individual's deterioration psychologically and socially due to the side effects caused by the disease and its treatments, which in most cases has strong side effects. In this project, a new approach was proposed for the treatment of cancer, focused on the synthesis, characterization and study of the in vitro anticancer activity of 1,3,4-Oxadiazole compounds derived from semicarbazones from vanillin. These compounds have aroused interest in the scientific community due to their notable anticancer activity, and not only because of this, reduction of the compound's lipophilicity, high ADME property (absorption, distribution, metabolism and excretion) and several already synthesized drugs containing the oxadiazole ring are also included as a strong attraction for scientific studies. The 1,3,4-Oxadiazoles that will be synthesized come from the cyclization of their respective semicarbazone, which in turn will be synthesized by the addition of the chosen semicarbazide with vanillin in glacial acetic acid. Tests on the anticancer activity of compounds synthesized in the laboratory will be carried out on human cell lines A549 (lung carcinoma), and on the normal human cell line MRC5 (lung fibroblast).