Phenotypic modulation of monocyte subtypes and microparticles by physical training in individuals with obesity

• Grant number: 23/18019-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2024
• End date: July 31, 2025
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Carolina Nunes França
• Grantee: Daniela Alves de Abreu
• Host Institution: Universidade de Santo Amaro (UNISA). São Paulo , SP, Brazil

Abstract

Obesity is a chronic disease that affects millions of people worldwide. The prevalence of overweight and obesity currently affects approximately 39% of the world population. Monocytes play a central role in the chronic inflammatory process, and studies show that obesity promotes modulation in the phenotype of the three subtypes of monocytes classified as classic (CD14++CD16-), intermediate (CD14++CD16+) and non-classical (CD14+CD16++). Microparticles are structures released by different cell types, after stimuli such as activation or apoptosis. Although it is accepted that physical exercise brings benefits associated with obesity, its modulation in subtypes of monocytes and microparticles is still little known. Thus, the objective of the present study is to evaluate a possible modulation of monocyte subtypes and circulating microparticles in obese individuals, after high-intensity interval training, compared to untrained individuals. Obese individuals (approximately n = 84), sedentary, of both sexes, aged between 18 and 60 years, will be invited to voluntarily participate in the present study and then separated into two groups: trained (three weekly HIIT sessions, for eight weeks) and untrained group (control). Assessment of body composition will be carried out by DEXA, before and after the training period.