EFFECTS OF HYDROLYZED PROTEIN INGESTION ON THE METABOMICS OF HEALTHY AND OBESE DOGS

• Grant number: 24/08489-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2024
• End date: August 31, 2025
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Animal Nutrition and Feeding
• Principal Investigator: Thiago Henrique Annibale Vendramini
• Grantee: Camila Oliveira Carneiro
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Obesity is a nutritional condition that is responsible for inducing a chronic inflammatory state capable of altering metabolism and predisposing the animal to a series of chronic diseases. According to studies in humans and rodents, hydrolyzed protein is capable of increasing insulin sensitivity and glucose tolerance and can minimize these changes in obesity. However, studies on the canine species are scarce. Therefore, the hypothesis of the present study is that hydrolyzed liver protein has an influence on the metabolism of obese dogs. Therefore, the objective is to evaluate the effects of including 5% CHX liver protein hydrolyzate in the diet on the metabolome of healthy and obese dogs. Two experimental groups will be included, respectively, the control group, consisting of six obese dogs that will receive a control diet, formulated with chicken protein; and the experimental group, consisting of six obese dogs that will receive a diet formulated with 5% liver protein hydrolyzate. Metabolomics parameters will be analyzed. Parametric and non-parametric statistical tests will be used to analyze the results and values of p<0.05 will be considered significant. The expected result is that groups of animals that are fed a diet that includes hepatic protein hydrolyzate will have a modulated metabolomic profile. Finally, it will be possible to conclude whether the inclusion of liver protein hydrolyzate can be a more advantageous alternative in relation to traditional protein sources for the management of dogs affected by obesity.