Comparative evaluation of humoral immune responses triggered by Haemonchus contortus in three sheep breeds carrying different beta-globin haplotypes

• Grant number: 24/13555-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2024
• End date: July 31, 2025
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Principal Investigator: Ana Carolina de Souza Chagas
• Grantee: Emanuelle Martins de Campos
• Host Institution: Embrapa Pecuária Sudeste. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
• Associated research grant: 21/02535-5 - Parasite-host-environment approach to control anthelmintic resistance in sheep flocks, AP.TEM

Abstract

Three sheep breeds (Santa Inês, Texel, and White Dorper) carrying different beta-globin haplotypes (AA, AB, and BB) will be comparatively evaluated during natural infection with H. contortus. The levels of anti-H. contortus (ES24 protein) antibodies of the IgG, IgA, and IgM isotypes will be assessed systemically (serum) and locally (nasal and abomasal mucosa).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OKINO, CINTIA HIROMI; BELLO, HORNBLENDA JOAQUINA SILVA; NICIURA, SIMONE CRISTINA MEO; MELITO, GLAUCIA ROBERTA; DA CUNHA, AMANDA FREITAS; DA COSTA, ESTEVAO CAMILLO; DE CAMPOS, EMANUELLE MARTINS; KAPRITCHKOFF, RAFAELA TAMI IKEDA; MINHO, ALESSANDRO PELEGRINE; ESTEVES, SERGIO NOVITA; et al. Haemonchus contortus parasitic stages development and host immune responses in lambs of different sheep breeds. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 284, p. 9-pg., 2025-04-23. (24/13543-7, 21/02535-5, 22/00776-8, 24/13555-5)