COMPARISON OF SERUM AND SALIVARY DOSAGE OF IL-6 AND PGE2 IN CATS WITH ORAL INFLAMMATORY DISEASES

• Grant number: 24/12791-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2024
• End date: September 30, 2025
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Principal Investigator: Cristina de Oliveira Massoco Salles Gomes
• Grantee: Nicoly Fialho de Souza
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Oral inflammatory diseases in cats are common and generally associated with a serious decline in quality of life and systemic repercussions beyond the oral cavity. In domestic cats, three main conditions occur frequently: periodontal disease, affecting almost all adult cats; feline chronic gingivostomatitis, described by ineffective treatments and relapses; and the feline tooth resorption lesion, of unknown etiology. These conditions cause an inflammatory process that, over the long term and in an exacerbated form, causes more discomfort, tissue destruction and a focus of chronic inflammation. In this scenario, several inflammatory mediators are released in an attempt to restore the function of oral epithelia. Among them, Interleukin-6 (IL-6) and Prostaglandin-E2 (PGE2) are important biomarkers of inflammation, extremely trained in humans due to the worsening of oral inflammations, however, in veterinary medicine, there is a lack of studies that correlate the presence of these in the oral cavity and the progression of diseases. Biomarker assessment helps us understand the role of inflammation in the etiopathogenesis of oral conditions, the etiology and triggers that trigger the dysregulation of the inflammatory process and its systemic action. The method of measuring IL-6 and PGE2 through gingival crevicular fluid is already widely practiced in human dentistry, and its potential in veterinary medicine is invaluable. It is considered a non-invasive, outpatient, practical method that enables the development of new methods of diagnosis, prognosis and therapeutic monitoring for oral conditions, which, to this day, is based on the descriptive power of visualization of clinical symptoms, a subjective and somewhat specific method. Therefore, the present work aims to compare the measurements of IL-6 and PGE2 in the gingival crevicular fluid and serum of cats with oral inflammation and healthy cats, describing the potential of the technique as a quantitative diagnostic method and correlating the presence of these biomarkers with the presence of oral inflammation in cats.