Hot and cold cognition in patients with depressive episode during magnetic and electro convulsive therapies: data from a randomized clinical study

• Grant number: 24/06902-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2024
• End date: October 31, 2026
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Ricardo Alberto Moreno
• Grantee: Adriana Carneiro
• Host Institution: Instituto de Psiquiatria Doutor Antonio Carlos Pacheco e Silva (IPq). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated scholarship(s): 25/04835-7 - A predictive dimensional and circuit-based analysis of thought distortion and suicide ideation in treatment-resistant depression patients following neuromodulation therapies, BE.EP.PD

Abstract

Cognitive alterations, both cold (emotion-independent) and hot (emotion-dependent), are common in depressive episodes and may persist even after treatment. The higher the number of previous episodes, the worse the recovery. This way, searching for more effective treatment methods with lower relapse rates and cognitive impacts is necessary. Objective: This study will investigate cognitive changes in mood disorders patients undergoing convulsive therapy (magnetoconvulsotherapy-MST or electroconvulsive therapy-ECT). Methods: The study will include 100 patients diagnosed with Depression or Bipolar Disorder by structured psychiatric interview (MINI) in moderate or severe depressive episode according to the Hamilton Depression Scale (HAMD equal to or greater than 17). They will be randomized to receive MST or ECT, in a 1:1 ratio, with sessions twice a week. Participants will answer instruments that will investigate hot cognitions (Beck Depression Inventory- BDI II, Beck Suicide Inventory- BSI, Autobiographical Memory Test- AMT, Depression Thoughts Scale-DTS) and cold cognitions (Weschler Scale - Estimated IQ, Rey Auditory Memory- RAVLT, Brief Visual Memory Test- BVMT, Trail Making Test- TMT A and B, Five Digit Test- FDT and FAS). Functional magnetic resonance imaging data will be collected pre- and post-ECT/MST. Professionals enrolled for assessment unaware of treatment assignment. Outcomes: The results will be analyzed to answer (1) whether hot or cold cognition can be a predictor of treatment response, (2) possible mediations of cognition in the context of the depressive episode, and (3) differences between convulsive techniques in the cognition of these patients. It is expected that patients undergoing magnetoconvulsotherapy will have better performance on cognitive tests. It is estimated that the results may guide the treatment of this area, as well as facilitate the detection of action mechanisms linked to the improvement of the depressive episodes.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARNEIRO, ADRIANA MUNHOZ; DA SILVA, PEDRO HENRIQUE RODRIGUES; DA SILVA, VALQUIRIA APARECIDA; BRUNONI, ANDRE RUSSOWSKY. No relation between fMRI findings and thought distortion in mood disorder? A claim for new studies. FRONTIERS IN PSYCHIATRY, v. 16, p. 3-pg., 2025-03-07. (18/10861-7, 22/03266-0, 24/06902-0, 19/06009-6)

CAVENAGHI, VITOR BRESEGHELLO; CARNEIRO, ADRIANA M.; CRETAZ, ERIC; CABRAL, BIANCA; CARDOSO, CAROLINE BENIGNO; BRUNONI, ANDRE RUSSOWSKY. Magnetic seizure therapy for unipolar and bipolar depression: An up to date systematic review. WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, v. 26, n. 1, p. 11-pg., 2024-12-18. (19/06009-6, 24/06902-0)