Exploring chaperone genes from extreme environments: new insights into stress resistance in bacteria

• Grant number: 24/15967-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2024
• End date: June 30, 2025
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Principal Investigator: María Eugenia Guazzaroni
• Grantee: Beatriz da Silva Mello
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Microorganisms in stressed environments possess significant genetic potential. Examples include adaptations to variations in temperature, radiation, salinity, acidity, or pressure. By studying microbial diversity, with an emphasis on the metabolic activities of these microorganisms, it is possible to uncover the biochemical strategies that enable their survival. These discoveries represent significant advancements in industrial processes, as bacteria are widely used in this sector. In this context, a specific group of proteins, chaperones, play a crucial role in protein folding, unfolding, and maintaining protein homeostasis. These mechanisms are essential for survival in stressful environments, promoting tolerance to various environmental conditions. Therefore, the goal of this research project is the functional characterization of chaperone-encoding genes, identified through an in silico approach using metagenomic databases. This work will determine the potential to enhance resistance under various abiotic stress conditions in bacteria.