ANALYSIS OF THE RELATIONSHIP BETWEEN DIFFERENT INTENSITIES OF PHYSICAL ACTIVITY AND PULSE WAVE VELOCITY IN ADULTS: EPIDEMIOLOGICAL STUDY

• Grant number: 24/16254-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2024
• End date: November 30, 2025
• Field of knowledge: Health Sciences - Collective Health - Epidemiology
• Principal Investigator: Diego Giulliano Destro Christofaro
• Grantee: Maria Eduarda Martins Vigilato
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Introduction: Cardiovascular diseases are among the diseases that cause the most mortality and costs to health systems. Therefore, there are risk factors and adverse consequences for these diseases, such as arterial stiffness, which discusses changes in the distensibility, compliance and elasticity of the artery. This increased stiffness can cause an increase in "pulse wave velocity", in which increases in the pressure wave that are in sharp values ¿¿can cause cardiovascular overload. In this sense, physical activity can contribute to a lower pulse wave velocity, but the best intensity of physical activity (light, moderate, vigorous) for this reduction is still not consensual. Objectives: To analyze the relationship between the different intensities of physical activity and arterial stiffness in adults from a city in southeastern Brazil, and to verify whether possible relationships between physical activity and arterial stiffness are independent of covariates such as sex, age and socioeconomic status. Methods: Individuals <18 years old (~145 adults) will be selected. Arterial stiffness will be assessed by pulse wave velocity using a noninvasive oscillometric device called Arterios AOP, which will perform 3 measurements in total (with a one-minute interval between measurements) and provide the pulse wave velocity measurement at the end. Physical activity (light, moderate and vigorous) will be recorded using the Actigraph GT3X accelerometer device (ActiGraph, LLC, Pensacola, FL, USA). The mean, standard deviation, median and interquartile range will be used for statistical analysis, along with linear regression and quantile regression, with a statistical significance of 5% and a 95% confidence interval. The statistical package used will be SPSS version 23.0.