Reductive Amination Reactions under Electrosynthesis Conditions Applied to the Synthesis of APIs: Batch and Continuous Flow Studies

• Grant number: 24/11868-6
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: December 01, 2024
• End date: February 28, 2029
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Kleber Thiago de Oliveira
• Grantee: Gabriel Hiroshi Seki Rosa
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

In this PhD project we propose to carry out a systematic study of reductive amination reactions via electrochemistry. Various reaction aspects will be evaluated with a focus on the selection of the best electrodes and the best activation surface techniques for these electrodes, in addition to different solvents, supporting electrolytes, pH and temperatures. The use of photoelectrocatalysis to activate electrodes with visible light should also be tested.The methodological studies will involve batch conditions with subsequent transposition to continuous flow conditions. In a final step, we intend to apply this methodology in the synthesis of some active pharmaceutical ingredients (IFAs), namely: tetracaine, haloperidol, and buspirone