PALLADIUM (II) COMPLEXES CONTAINING 3,5-DIMETHYLPYRAZOLYL-1-IMINOTHIOLATES: SÍNTHESIS, CHARACYERIZATION AND CYTOTOXIC EVALUATION AGAINST BREAST CANCER CELLS

• Grant number: 24/15273-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2024
• End date: July 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Adelino Vieira de Godoy Netto
• Grantee: Pedro Henrique Sêneda Silveira
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Breast cancer is one of the main types of malignant tumors that affect women. The percentage of new cases of female breast cancer predicted for Brazil between 2023 and 2025 (10.5%), represents around 74 thousand cases, that is, a risk of 66.54 new cases for every 100 thousand women. Carboplatin is indicated in combination therapy with other chemotherapy drugs or anti-HER2 agents for the treatment of breast cancer in different scenarios (neoadjuvant, adjuvant and metastatic). Although carboplatin are highly toxic to cancer cells, their low selectivity causes them to interact with cells from other tissues in the body, leading to various side effects in patients. Thus, the search for new complexes with better selectivity and fewer adverse effects has been encouraged, resulting in the synthesis of new metal-based molecules with different metal centers. Particularly, the class of thiocarbamoylpyrazole molecules are compounds has been used for the synthesis of bioactive Pd(II) complexes. This proposal aims to synthesize and evaluate the antitumor potential of the [PdCl(R-tdmPz)(PR3)] type (R = p-nitrophenyl, p-fluorophenyl and p-methoxyphenyl; PR3 = triphenylphosphine and p-substituted aromatic phosphines ( -CH3 and -OCH3).The characterization of the synthesized complexes will be carried out using spectroscopic techniques in the infrared (IR) region, in the ultraviolet and visible (UV-Vis) region, nuclear magnetic resonance (NMR), mass spectrometry, elemental analysis, and crystallographic studies (in case of obtaining single crystals). The antiproliferative effects of the complexes on breast tumor cells will be investigated. The most promising compounds will be subjected to interaction tests with DNA and human serum albumin (HSA).