Conformacional and biological studies of antithrombin purified from human plasma in the presence of heparins bearing different structural modifications

• Grant number: 24/18161-5
• Support Opportunities: Scholarships in Brazil - Program to Stimulate Scientific Vocations
• Start date: May 12, 2025
• End date: June 26, 2025
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Helena Bonciani Nader
• Grantee: Weendell Torres Botelho da Silva
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The project seeks to understand how heparin interacts with antithrombin, an essential protein in the coagulation process, and how this interaction influences its ability to inhibit angiogenic processes, such as the formation of new blood vessels. Studies suggest that chemical modification of heparin may alter antithrombin's antiangiogenic activity, offering a potential therapeutic approach to regulate angiogenesis in pathological conditions. (AU)