Study of the interrelationship between angiosomes and their dysfunction in kidney and liver organs in the acute phase of sepsis.

• Grant number: 24/20436-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2025
• End date: December 31, 2025
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Ivan Hong Jun Koh
• Grantee: Gabriel Antônio de Oliveira
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

The results achieved by the FAPESP IC project No. 2023/07392-3 showed that the light resin (Mercox II Resin) perfuses the microvessels, making it possible to study the three-dimensional architecture of the microvascular bed of organs such as the kidney and liver. In sepsis, a state of microhemodynamic dysfunction occurs systemically and the lack of technology to monitor the stage of organ impairment has made it difficult to establish a prognosis and therapeutic management based on the state of microcirculatory dysfunction. The objective of this research is to evaluate the three-dimensional morphofunctional adaptation of the microcirculation in organs in the acute phase of sepsis. The animals will be induced to sepsis and the kinetics of microcirculatory dysfunction in the first six hours will be examined by injection of the light resin that, after tissue corrosion, will be examined using scanning electron microscopy. A better understanding of microcirculatory adaptation in acute sepsis, in a three-dimensional way, may help us elucidate the dynamic microcirculatory adaptation in response to critical illness, which is still little known.