Dietary choices and postprandial metabolism in women.

• Grant number: 24/03708-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: April 01, 2025
• End date: December 31, 2025
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Jarlei Fiamoncini
• Grantee: Giovanna Moreira Silva
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 22/02941-6 - Bile acids as determinants of postprandial metabolism and intestinal microbial colonization in newborns, AP.PNGP.PI

Abstract

Postprandial metabolism encompasses a series of physiological processes that occur after food ingestion. Imbalance in these processes leads to metabolic disorders and the emergence of non-communicable chronic diseases (NCDs). Dietary pattern and gender are relevant factors influencing postprandial responses, and the increasing prevalence of NCDs in women underscores the importance of understanding the relationship between diet and postprandial metabolism in this population. The present proposal aims to identify the relationship between dietary pattern and postprandial responses in women of different age groups and body mass index (BMI) ranges. For this purpose, 100 women aged 18 to 70 years with BMI between 18.5 and 34.9 kg/m² will be invited to participate in the study to map the diversity of postprandial responses through a dietary challenge, consisting of the ingestion of a high-calorie meal. Seven capillary blood samples will be collected: the first after a 10-hour fasting and six other within 5 hours after the ingestion of the meal. Plasma levels of glucose, circulating free fatty acids, and triglycerides will be quantified. A dietary frequency questionnaire will be administered, and daily nutrient intake determined according to the Brazilian Food Composition Table. It is expected that this study will identify the relationship between dietary pattern and postprandial metabolic responses, thereby contributing to a better understanding of dietary choices and their effects on postprandial metabolism in women, as well as aiding in the development of appropriate nutritional strategies for this population.