Effect of cytoprotective molecules on neurogenesis and neuroprotection processes in cell culture.

• Grant number: 25/00998-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2025
• End date: February 28, 2026
• Field of knowledge: Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
• Agreement: GlaxoSmithKline
• Principal Investigator: Vanessa Olzon Zambelli
• Grantee: Larissa Gonzaga Santos Kiataki
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Company: Secretaria da Saúde (São Paulo - Estado). Instituto Butantan
• Associated research grant: 20/13139-0 - Centre of Excellence in New Target Discovery, AP.PCPE

Abstract

Our research group focuses on identifying and validating molecular targets with anti-inflammatory and/or anti-nociceptive potential. To this end, peptides derived from venoms, aswell as extracts and secretions from various animals are used.Through the application of advanced techniques such as transcriptomics, proteomics, andchemoproteomics, novel molecular targets were identified. To investigate their functions anddetermine the biological processes linked to diseases under study, molecular tools, includingRNA interference, CRISPR/Cas9 genome editing, and target overexpression, were used in cellculture.Promising results have been achieved in cell culture models of neuronal (Alvarez-Flores et al. J.Neurochemistry, 2019, v.148) and articular inflammation (Alvarez AM et al. Front. Mol.Biosci., 2022, v.9). Therefore, this project aims to evaluate the neuroprotective anti-inflammatory and anti-nociceptive effect of these molecules in in vivo models of brain injuryand neuropathic pain.