Development of 3D Printing Inks based on hyaluronic acid aimed at application in controlled drug release

• Grant number: 24/23271-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2025
• End date: March 31, 2026
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Hernane da Silva Barud
• Grantee: Matheus Crivelenti Abrão
• Host Institution: Universidade de Araraquara (UNIARA). Associação São Bento de Ensino. Araraquara , SP, Brazil

Abstract

Three-dimensional (3D) printing is a revolutionary technique that uses computation to process raw materials, resulting in materials with sophisticated architectures. Its applicability is vast, fostering interactions and collaborations in the advancement of science, engineering, and high-tech industry. The properties of raw materials are crucial for 3D printing, influencing their processability, shape maintenance, and functionality. Aiming at the development of sustainable alternatives with additional functionalities for 3D printing inks, biopolymers are a promising option and a necessary step towards the advancement of this area. Among biopolymers, hyaluronic acid is particularly relevant, as it stands out for its biocompatibility and highly hydrophilic capacity, with significant therapeutic properties. This project proposes the fabrication of a three-dimensional drug delivery system, through the development of a biocompatible and biodegradable ink based on hyaluronic acid and gelatin hydrogels, with the addition of cellulose nanocrystals as a reinforcement material, seeking to improve mechanical properties. Furthermore, aiming at the formation of a drug delivery system in which an antimicrobial, ciprofloxacin, will be used. Furthermore, in order to reduce the formation of toxic residues during the crosslinking process, it is planned to use a natural crosslinker, genipin, which not only has low toxicity but also exhibits promising anti-inflammatory properties.