Effects of bile acids in adult women postprandial inflammatory response

• Grant number: 24/05571-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2025
• End date: April 30, 2027
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Jarlei Fiamoncini
• Grantee: Rodolfo Cabral Marcelino
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 22/02941-6 - Bile acids as determinants of postprandial metabolism and intestinal microbial colonization in newborns, AP.PNGP.PI

Abstract

The nutrients that make up a meal and intrinsic factors of each individual are responsible for determining postprandial responses, which present high interindividual variability. Among the changes observed in the postprandial period, there is a transient inflammatory response that is related to the development of chronic diseases. The increase in the circulating concentration of bile acids (BA) is also a characteristic phenomenon of the postprandial period. BA have received attention due to reports of their anti-inflammatory potential and modulation of energy metabolism, demonstrated in preclinical studies. The present study seeks to evaluate whether BA influence postprandial inflammation in women of a wide age and BMI range. This study will include 100 women who will undergo a dietary challenge to evaluate the kinetics of BA in plasma during the postprandial period. Based on this data, a new dietary challenge will be carried out to verify the postprandial responses of the 20 women with greater and lesser increases in circulating BA concentration in the postprandial period. Among other things, the plasma concentration of inflammatory cytokines and gene expression of circulating leukocytes will be evaluated. The results of this study can contribute to the identification of mechanisms involved in the development of chronic diseases associated with postprandial inflammation and to increase knowledge about the effects of BA on the body.