Liver Transplantation Outcomes in Patients with Secondary Biliary Cirrhosis

• Grant number: 25/05250-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2025
• End date: April 30, 2026
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Wellington Andraus
• Grantee: Eduardo Pereira Massabki
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Design: A total of 42 previously selected patients with a history of liver transplantation for the treatment of secondary biliary cirrhosis (SBC), resulting from bile duct injuries sustained during cholecystectomies, will be analyzed. A retrospective study will be conducted using data collected from both transplanted patients and their respective donors.Objectives: To evaluate how liver transplantation influences the progression of patients with secondary biliary cirrhosis following bile duct injury during previous cholecystectomy.Background: Bile duct injury (BDI) is a serious and frequent complication of cholecystectomies. Some patients may develop secondary biliary cirrhosis (SBC) in the long term. Liver transplantations come as the only treatment available for this disease profile.Methods: Observational retrospective study from a prospective LT database. 42 patients who developed SBC after a cholecystectomy between January 1986 and December 2024 were included. Long-term outcomes were analyzed. (AU)