IN VITRO AND IN VIVO SAFETY ASSESSMENT OF A HYDROGEL-REPELLENT PROTOTYPE CONTAINING MYRCENE ASSOCIATED WITH CYCLODEXTRINS

• Grant number: 25/03985-5
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• Start date: September 01, 2025
• End date: February 28, 2026
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marlus Chorilli
• Grantee: Felipe Mota Tashiro
• Supervisor: Ana Melero Zaera
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: Universitat de València, Spain
• Associated to the scholarship: 24/06522-3 - EVALUATION OF A HYDROGEL REPELLENT PROTOTYPE CONTAINING MYRCENE ASSOCIATED WITH CYCLODEXTRINS, BP.MS

Abstract

Arboviruses are diseases transmitted by hematophagous arthropods, especially the Aedes genus. As neglected diseases have difficulty accessing specific treatment, the use of repellents is described as the best form of prevention. Formulations with synthetic active repellents are widespread on the market. However, they can create risks for the user, as well as damage the environment. In addition, these vectors are gaining resistance over traditional repellent actives. The use of secondary metabolites from plant species, such as myrcene, a monoterpene with proven repellent activity, is an alternative to the development of new products. However, these substances show high volatility, requiring a greater number of reapplications for effective protection. To overcome this problem, the use of matrices capable of controlling the rate release of the active ingredient, such as cyclodextrins, associated with the use of formulations capable of providing greater adhesion, reducing skin permeation, and the formation of uniform films on the skin, hydrogels, is an option. Therefore, this research internship project proposal work will focus on understanding the hydrogel-repellent prototype with myrcene complexed with ¿-cyclodextrin behavior on skin permeability, retention, in vitro cytotoxicity, and in vivo delayed hypersensitivity to safety assessment.