STUDY OF THE EFFECTS OF STATIC MAGNETIC FIELD AND RED LIGHT IRRADIATION ON GENE EXPRESSION OF HUMAN KERATINOCYTES AND IN BIOMIMETIC MEMBRANE MODELS.

• Grant number: 24/20671-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2025
• End date: February 28, 2029
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Mauricio da Silva Baptista
• Grantee: Arthur Pereira Ribas
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Photobiomodulation has gained prominence in clinical and aesthetic applications as a promising alternative for treating ulcers, chronic pain, neural regeneration, and skin photorejuvenation. In vivo and in vitro studies show that light in the red wavelength range can significantly alter cellular functions, promoting effects such as proliferation, cytokine secretion, differentiation, and cellular regeneration.At the same time, magnetic fields also demonstrate potential to modulate these same activities in in vitro cellular systems. However, the molecular mechanisms underlying these phenomena are not yet fully elucidated, especially concerning the effects induced by magnetic stimuli.This project aims to apply transcriptomic analyses to investigate cellular responses to magnetic and light stimuli, focusing on gene expression. Additionally, studies using biomimetic membrane models will be conducted to understand how these biological structures specifically respond to red light and magnetic fields. The combination of these approaches will provide a detailed view of the molecular and biophysical mechanisms involved, contributing to the understanding of the therapeutic and cellular effects promoted by these stimuli. (AU)