Development of an Anti-Inflammatory Microemulsion Containing Lavandula angustifolia Essential Oil and Betamethasone for Psoriasis Treatment

• Grant number: 25/07356-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2025
• End date: June 30, 2026
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Lucas Amaral Machado
• Grantee: Lívia Fernanda Callovi Cazarin
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

Psoriasis is a chronic, immune-mediated inflammatory disease that affects approximately 60 million people worldwide, significantly impairing quality of life. Topical treatment is essential, especially in mild to moderate cases, with corticosteroids such as betamethasone widely used. However, prolonged use can lead to adverse reactions, such as allergic contact dermatitis, as well as low adherence due to sensory discomfort. Calcineurin inhibitors, although effective, are costly and carry a risk of skin irritation. Moisturizing agents, such as emollients and humectants, are frequently used as adjuvants and may be combined with natural and synthetic active ingredients. Lavender essential oil, for example, has anti-inflammatory and regenerative properties, modulating pro-inflammatory cytokines. However, its direct application may cause unpleasant skin sensations, compromising treatment acceptance. In this context, microemulsions emerge as promising nanotechnological systems capable of delivering lipophilic compounds such as betamethasone and lavender oil. These systems offer greater stability, skin penetration, and reduced adverse effects, while also enabling more efficient active ingredient release. This project aims to develop and characterize a microemulsion containing betamethasone and lavender essential oil for the topical treatment of psoriasis. The proposal seeks to provide an innovative, safe, and sensorially pleasant alternative, promoting greater adherence and efficacy in disease management. (AU)