Follow-up of the metabolism of histidine and BCAA in Trypanosoma cruzi and Trypanosoma brucei: a metabolomic and lipidomic analysis

• Grant number: 25/09884-6
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Start date: November 24, 2025
• End date: November 23, 2026
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Ariel Mariano Silber
• Grantee: Sabrina Del Carmen Marsiccobetre Castaneda
• Supervisor: Michael Barrett
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of Glasgow, Scotland
• Associated to the scholarship: 22/09116-0 - Study of the metabolic flux to analyze the relationships between biochemical pathways of amino acids and biological processes of Trypanosoma cruzi, BP.PD

Abstract

This proposal aims to assess whether the production of particular metabolites and lipids is modified in mutants of the selected amino acid metabolic pathways and whether these metabolites create connections between different metabolic pathways, by applying metabolomics and lipidomics in the selected mutant lines