Development of Mucoadhesive Films Loaded with Prebiotics and Postbiotics for Vaginal Microbiota Rebalancing

• Grant number: 25/01868-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: August 01, 2025
• End date: October 31, 2026
• Field of knowledge: Engineering - Chemical Engineering
• Principal Investigator: Mariana Agostini de Moraes
• Grantee: Maria Eduarda Sousa Fonseca
• Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 25/23105-0 - Biological Activity and Permeability Evaluation of Mucoadhesive Polymeric Films Loaded with Prebiotics and Postbiotics for Vaginal Microbiota Rebalancing, BE.EP.MS

Abstract

This project aims to develop a mucoadhesive film based on chitosan and mucin, enriched with prebiotics and postbiotics, focusing on the rebalancing of the vaginal microbiota, a topic that is still underexplored in scientific literature. Unlike formulations focused on directly combating opportunistic microorganisms, which can cause secondary imbalances or adverse effects, this proposal stands out for its innovative approach of promoting an environment conducive to the restoration of the vaginal microbiota. This strategy aims to prevent or treat vaginal dysbiosis and associated complications, such as candidiasis, often resulting from antibiotic use. In addition to promoting women's health and well-being, it aligns with the United Nations Sustainable Development Goal 3 (SDG 3), which seeks to ensure healthy lives and promote well-being for all. Beyond the health impact, the use of natural polymers like chitosan and mucin reinforces the alignment with Sustainable Development Goal 12 (SDG 12), which encourages sustainable consumption and production patterns by employing biodegradable materials with low environmental impact. The methodology includes the formulation of chitosan and mucin blends and their physicochemical characterization (FTIR, DSC, XRD, TGA), mechanical property analysis, degradation and swelling, mucoadhesion strength, and biological tests to assess safety and efficacy, with special attention to the impact on the vaginal microbiota. This study seeks to make a significant contribution to advances in women's health by presenting an innovative, sustainable, and efficient solution.