Genotypic and Phenotypic Analysis of the Resistance Profile of Influenza Viruses A and B, which affect Pediatric Patients

• Grant number: 25/13042-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2025
• End date: July 31, 2026
• Field of knowledge: Biological Sciences - Microbiology - Applied Microbiology
• Principal Investigator: Edison Luiz Durigon
• Grantee: Luiza Sanches Lourenço
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 23/07746-0 - Drug discovery against human viral infectious diseases, AP.TEM

Abstract

Acute respiratory infections (ARIs) are the most frequent infectious diseases in humans and most respiratory infections observed in medical practice around the world are of viral etiology. Despite the vast number of viral agents involved in respiratory infections and its clinical importance, the Influenza virus (Flu) is one of the few that has a known and acceptable treatment. Today, in addition to the vaccine, only 4 anti- influenza drugs have been licensed by the FDA and resistance patterns to all of them have been described. The most reported mutations related to resistance to Neuraminidase Inhibitors (IsNA) are E119V, H274Y, R292K and N294S. The emergence of resistant strains to viral treatment, associated with the lack of knowledge about the prevalence of such mutations in clinical samples worldwide, shows us the need for detailed epidemiological investigations and emphasizes the need to monitor IsNA mutant strains in seasonal influenza. , which circulate in Brazil today: A-H1N1, H3N2 and pH1N1. (AU)