Differences between circulating micrornas in pooled samples from individuals with normal weight, obese weight, and type 2 diabetes.

• Grant number: 25/14202-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2025
• End date: July 31, 2026
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Claudia Regina Cavaglieri
• Grantee: Matheus Chiaradia Greguer
• Host Institution: Faculdade de Educação Física (FEF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 24/13126-7 - COMBINED TRAINING ANSWERS ON THE EXPRESSION OF CIRCULATING MICRORNAS IN EUTROPHIC, OBESE AND WITH TYPE 2 DIABETES INDIVIDUALS, AP.R

Abstract

Obesity (T2D) affects a large number of individuals in Brazil and worldwide. Excess body fat is associated with a chronic low-grade inflammatory state, which increases the risk of developing cardiometabolic diseases. One of the mechanisms associated with cardiometabolic control is the secretion of serum regulators with endocrine functions, including small non-coding ribonucleic acids/microRNAs (miRNAs). MiRNAs have diverse functions, such as controlling adipose tissue, inflammation, glycemia, the cardiovascular system, and protecting against neurodegenerative diseases and cancer, among other aspects. Obesity appears to favor a miRNA expression and secretion profile that favors the development of cardiometabolic diseases. Physical training, on the other hand, can modulate the expression and secretion of several of these small nucleotides, with results often going in opposite directions to those associated with obesity. The combined practice of strength and aerobic training, known as combined training (CT), has been increasingly used and recommended, as it induces benefits from both types of exercise. Additionally, both strength and aerobic training appear to modulate miRNAs. However, these training effects have been evaluated on specific miRNAs, and the overall influence on these markers is unclear, especially when assessed in extracellular vesicles. Therefore, evaluations are needed that focus on analyzing the effects of CT on global miRNA expression in pooled samples of extracellular vesicles from obese individuals.