RESISTANCE TRAINING AS A STRATEGY FOR MODULATION OF LIPID PROFILE IN ADOLESCENTS AND ADULTS WITH DYSLIPIDEMIA: SYSTEMATIC REVIEW WITH META-ANALYSIS

• Grant number: 24/23797-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2025
• End date: July 31, 2026
• Field of knowledge: Health Sciences - Physiotherapy and Occupational Therapy
• Principal Investigator: Alan José Barbosa Magalhães
• Grantee: Maria Eduarda Maschio
• Host Institution: Instituto Municipal de Ensino Superior de Assis. Fundação Educacional do Município de Assis (FEMA). Assis , SP, Brazil

Abstract

Introduction: Resistance training is a low-cost method for managing dyslipidemia, and the literature describes various modalities of this training employed in treating such patients.Objective: This study aims to evaluate the effects of resistance training on lipid profile parameters-total cholesterol, HDL, LDL, triglycerides-as well as body fat and visceral fat percentages in adolescents and adults with dyslipidemia, overweight, or obesity.Materials and Methods: This systematic review with meta-analysis will be conducted following the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions and has been prospectively registered in the International Prospective Register of Systematic Reviews (PROSPERO).Only randomized and non-randomized clinical trials that employed some form of resistance training and reported at least one lipid profile variable as an outcome will be included. The PICOT framework was used to structure the methodology, defining the population (adolescents and adults with dyslipidemia, overweight, or obesity), intervention (resistance training), comparators (control group with no intervention or placebo-type intervention), outcomes (total cholesterol, HDL, LDL, triglycerides, body fat percentage, and visceral fat percentage), and follow-up periods categorized as short-term (<12 weeks), medium-term (12-24 weeks), and long-term (24-48 weeks).Studies evaluating the efficacy of specific products or equipment, as well as trials with conflicts of interest, will be excluded. Study selection will be performed independently by two reviewers, with any disagreements resolved by consensus or consultation with a third reviewer.Risk of bias will be assessed using the PEDro Scale, and studies will be classified as having low, moderate, high, or very high risk of bias. In the meta-analysis, the effects of the various interventions will be compared with control groups and, when feasible, with one another.Statistical analyses will be conducted using Review Manager® software (RevMan version 5.3.5). Results will be synthesized using a meta-analysis and reported as standardized mean differences (SMDs) with 95% confidence intervals (CIs).This study will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for reporting and organization. The quality and certainty of the evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.