Influences of Sleep on Respiratory Alterations Observed in Parkinson's Disease

• Grant number: 25/11709-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: September 01, 2025
• End date: August 31, 2027
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Ana Carolina Takakura Moreira
• Grantee: Beatriz da Silva Franco
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 21/09768-5 - Influences of sexual dimorphism, inflammation and sleep on respiratory changes observed in Parkinson’s Disease, AP.TEM

Abstract

The etiology of Parkinson's disease (PD) is multifactorial, and current treatments are only partially effective, as the symptoms are not solely due to reduced dopamine release (Albers et al., 2017; Besedovsky et al., 2019; Chahine et al., 2017). Sleep disturbances are among the main symptoms that precede the classical motor signs of PD and include: dysregulation of the sleep-wake cycle, insomnia, excessive daytime sleepiness, REM sleep behavior disorder, sleep-related breathing disturbances, restless legs syndrome, circadian dysregulation, and obstructive sleep apnea (Videnovic, 2018; Zhu et al., 2020). In the present project, we aim to investigate whether respiratory alterations occur during sleep in a genetic model of Parkinson's disease (MitoPark).