Development of new solid forms of class II and IV drugs

• Grant number: 25/23031-6
• Support Opportunities: Scholarships in Brazil - Program to Stimulate Scientific Vocations
• Start date: January 05, 2026
• End date: February 15, 2026
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Yvonne Primerano Mascarenhas
• Grantee: Carolina Garcia Cardoso
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

The fellow will monitor ongoing research under the theme "Development of New Solid Forms of Class II and IV Drugs," led by Dr. Cecilia Carolina Pinheiro da Silva and Prof. Dr. Javier Ellena. The objective of this project is to develop novel structural drug designs through the strategic use of supramolecular synthons to obtain new salts and/or drug-drug cocrystals capable of offering pharmacokinetic and pharmacodynamic improvements compared to their separately administered ingredients. Samples of new multicomponent solid forms under study during the internship will be characterized using the following techniques: single-crystal and powder X-ray diffraction, Fourier transform infrared vibrational spectroscopy and Raman scattering, thermogravimetric analysis, and differential scanning calorimetry.