Exercise and prenatal brain development: a study in rat pups born from trained mothers during pregnancy

• Grant number: 10/11353-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2010
• End date: October 31, 2013
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Ricardo Mario Arida
• Grantee: Sérgio Gomes da Silva
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 09/06953-4 - Brain plasticity induced by physical exercise, AP.TEM

Abstract

In the last decades, many studies have been performed to the understanding of neurobiological bases of physical exercise to the maintenance and improvement of neural function in adult and elderly. Although the effects of physical exercise in the mature brain are well documented, its influence in the developing brain has been little explored. Events occuring during prenatal development may result in positive and negative changes to the brain throughout life. To this end, the present study aims to examine the influence of physical exercise on prenatal brain development. For this purpose, the brain-derived neurotrophic factor (BDNF) expression, tropomyosin-related kinase B receptor (TrkB), p75 neurotrophin receptor (p75ntr), cannabinoid receptor type 1 (CB1), conexins (Cx32, Cx36 e Cx43), cAMP response-element-binding protein (CREB), phosphoinositide 3-kinase (PI3K), mitogen regulated kinase (MEK), extracellular signal-regulated kinase (ERK), calcium/calmodulin-dependent protein kinase type 4 (CaMK4) will be analyzed at different stages of postnatal brain development (P1, P7, P21 and P60) of pups borned from trained mothers during pregnancy. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, SERGIO GOMES; DE ALMEIDA, ALEXANDRE APARECIDO; FERNANDES, JANSEN; LOPIM, GLAUBER MENEZES; CABRAL, FRANCISCO ROMERO; SCERNI, DEBORA AMADO; DE OLIVEIRA-PINTO, ANA VIRGINIA; LENT, ROBERTO; ARIDA, RICARDO MARIO. Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring. PLoS One, v. 11, n. 1, JAN 15 2016. (10/11353-3, 09/06953-4)