Effect of sinvastatin before and during pregnancy on tooth germ and palat in mouse embryos

• Grant number: 07/07401-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2008
• End date: December 31, 2008
• Field of knowledge: Biological Sciences - Morphology - Embryology
• Principal Investigator: Eleny Balducci Roslindo
• Grantee: Ludmilla Medeiros Faria
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The statin medicine is inhibitor HGM-CoA (hydroxymethylglutaryl - Coenzyme A), produces cellular responses like reducing the synthesis of LDL (low density lipoprotein) and VLDL (very low density lipoprotein). The HGM-CoA, from acetyl-CoA, is responsible for the release of mevalonate, an important precursor of cholesterol. So is indicated for the treatment of hyperlipidemia and hypercholesterolemia. The intense therapy indication has provided a significant turnover of billions of dollars annually to the Pharmaceutical Industry. Therefore, it became necessary to find its effects, especially in the early months of pregnancy, a period that occurs embryogenesis and organogenesis in the human body. This work aims at achieving the comparative study of the development of the palate and the development of dental germs of the first upper and lower molars of embryos of mice under the action of simvastatin during organogenesis.