Antarctic isolated bacterium as source of antifungal agents

• Grant number: 09/05970-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2009
• End date: December 31, 2010
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Ana Olívia de Souza
• Grantee: Daniela Leite de Oliveira
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

New antifungal drugs with specific activity or with wide action spectrum, in addition to minimal side effects are necessary to improve the treatment of fungal infections.There is a wide biodiversity in different ecosystems, which is only partially explored. The goal of this project aims to employ Antarctic isolated bacterium as source of new antifungal agents.Antifungal activity of organic extracts obtained from the culture of ~100 isolated bacteria will be assayed against the following pathogens: Candida albicans IOC 4525, Candida albicans IOC 3704/ATCC 36802, Aspergillus fumigatus IOC 4526, Trichophyton rubrum IOC 4527, Cryptococcus neoformans IOC 4528 and Cryptococcus neoformans ATCC 90112.The assayed bacteria that display antifungal activity will be identified (specie and genera) by their 16S rRNA (16S rDNA) sequencing.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, D. L.; GOMES, T. C.; MELO, I. S.; DE SOUZA, A. O.. Janibacter sp. Isolated from Deschampsia antarctica Rhizosphere as a Potential Source of Antimicrobial Compounds. BIOLOGY BULLETIN, v. 50, n. 3, p. 8-pg., 2023-04-10. (09/05970-2)