Analyis of genotypic profile of IL-10 and IL-18 genes in thyroid cancer patients

• Grant number: 08/08463-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2009
• End date: October 31, 2009
• Field of knowledge: Biological Sciences - Genetics - Human and Medical Genetics
• Principal Investigator: Laura Sterian
• Grantee: Lucas Leite Cunha
• Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Infiltrating lymphocytes and immature dendritic cells are usually found in well differentiated tumors like the papillary thyroid carcinoma. IL-10 cytokine controls the resolution of inflammation mainly regulating lymphocyte activation, dendritic cells and macrophages. IL-10 1082G allele produces more IL-10 than IL-10 1082A alelle. Interleukin-18 (IL-18) is a proinflammatory cytokine. Its promoter site has a polymorphism (+105A/C) whose function is still not clear but may be associated to immune response against cancer. The aim of this research is to investigate the influence of these polymorphisms on both the susceptibility and the outcome of well differenciated thyroid carcinomas.