Biocompatibility evaluation of hydroxyapatite nanoparticles in subcutaneous tissue of rats

• Grant number: 09/09935-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2009
• End date: August 31, 2010
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Alceu Sergio Trindade Junior
• Grantee: Elen Juliana Bonassa de Sousa
• Host Institution: Hospital de Reabilitação de Anomalias Craniofaciais (HRAC). Universidade de São Paulo (USP). Bauru , SP, Brazil

Abstract

The repair of bone defects is an objection to the rehabilitation treatment, especially when there is interventions in the hospital. The biomaterials with osteoinductive properties are the cause of studies that aim to find substitutes for human bone that can also be used as a material for the treatment of bone defects. Materials that present theirselves with particles measured in nanometers are easily phagocytized by macrophages making thus a bone of better quality without traces of osteoinductive material.The objective is to evaluate the biocompatibility of hydroxyapatite nanoparticles (test material) in rat subcutaneous tissue through histological cuts obtained after 3, 24 hours and 7, 21, 30 and 60 days from the implantation