Construction of a human transcription factors database

• Grant number: 07/08443-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2008
• End date: December 31, 2008
• Field of knowledge: Physical Sciences and Mathematics - Computer Science - Computing Methodologies and Techniques
• Principal Investigator: Ney Lemke
• Grantee: Luiz Augusto Bovolenta
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Transcriptions factors are DNA-binding proteins that regulate the transcription of genes through binding to regulatory sequences located upstream from the promoter region of genes. Due to their regulatory function, the identification and characterization of transcription factors are important for understanding determinant biological processes, as cell differentiation and apoptosis. The transcription factors data acquisition is not trivial since human transcription factors data are sparsely found in literature or in access paid databases. Thus, the construction of a freely accessible human transcription database would overcome these limitations. In this current project, we propose the construction of a freely accessible human transcription factors database containing the following data for each transcription factor: binding sites, regulated genes and references. This database will be made available for searching via a web interface.