Induction of protective immunity to bacterial injections by mucossal administration of biodegradable microspheres containing antigen and immunomodulator

• Grant number: 96/00687-9
• Support Opportunities: Scholarships abroad - Research
• Start date: August 16, 1996
• End date: August 15, 1998
• Field of knowledge: Biological Sciences - Biochemistry - Enzymology
• Principal Investigator: Maria Helena Bueno da Costa
• Grantee: Maria Helena Bueno da Costa
• Host Investigator: Gillian Barratt
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Institution abroad: Université Paris-Sud (Paris 11), France

Abstract

The aim of this project is to assess the efficacy of adding an immunomodulator, inter leukin-2 (IL-2), a cytokine which can stimulate both T helper cells and antibody-producing B cells, to microspheres containing PC-Thyr, in terms of inducing mucosal immu (AU)