Transient infrared spectroscopy of proteins and peptides

• Grant number: 00/14740-6
• Support Opportunities: Scholarships abroad - Research
• Start date: June 13, 2002
• End date: November 12, 2002
• Field of knowledge: Biological Sciences - Biophysics - Molecular Biophysics
• Principal Investigator: Marinônio Lopes Cornélio
• Grantee: Marinônio Lopes Cornélio
• Host Investigator: Robin M. Hochstrasser
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
• Institution abroad: University of Pennsylvania, United States

Abstract

The use of phase-controlled femtosecond IR pulses enables the full measurement of 2D vibrational spectra. These measurements are the direct IR analogues of the multidimensional spectra measured in NMR experiments including multiple quantum transitions. The Fourier transformed 2D-IR spectra provide information on couplings between modes and hence on peptide structure. These new methods are showing to be very promise for elucidating the dynamics of structures in biomolecule. (AU)