Abstract
The endoplasmic reticulum chaperone Protein disulfide Isomerase A1 (PDI) emerges as a novel organizer of redox signaling processes involving Nox NADPH Oxidases. Recent evidences from our group suggest that mechanisms for these effects involve direct PDI convergence with RhoGTPases such as Rac1 and their regulator RhoGDI. In this context, PDI and related proteins are regulators of cytoskel…