Abstract
Glycogen synthase kinase-3² (GSK-3²) is a multifunctional serine/threonine kinase found in all eukaryotes that was initially named for its ability to phosphorylate glycogen synthase, but it is now recognized as a key component of multiple signaling pathways. Extracellular stimuli inhibit GSK-3beta activity by different intracellular mechanisms (AKT, PKA, PKC), in opposition, certain tyros…