Abstract
PA-BJ is a Bothrops jararaca venom serine proteinase that triggers platelet-aggregation in a thrombin-like fashion by cleaving the protease-activated receptors PAR-1 and PAR-4 on platelets. We recently carried out a study to comparatively analyze the aggregation of platelets activated by thrombin, one of the most important platelet agonists, and PA-BJ. For this purpose, approaches of mass…