Lucas Cezar Pinheiro

• Abstract

  Sepsis is a complex syndrome with problematic definition and diagnosis. Sepsis treatment is complex, generally expensive and ineffective in sight of the high mortality rate of the septic patient. Recent data indicate, in Brazil, mortality due to sepsis of approximately 43.8%. During sepsis there is a significant increase in the production of nitric oxide (NO). The systemic increase of NO …

  Proteic nitrosylation: a critical mechanism and pharmacological target in severe sepsis, AP.JP

• Abstract

  Sepsis is a serious condition with great mortality. The worsening of sepsis may result in septic shock, in which a significant drop in blood pressure, usually refractory to vasoconstricting agents, occurs. Such events may be associated with increased nitric oxide formation and consequent increase in S-nitrosylation of proteins. The aim of the project is to evaluate whether there is an inc…

  Evaluation of total vascular S-nitrosylation in CLP septic animals, BP.IC
• Proteic nitrosylation: a critical mechanism and pharmacological target in severe sepsis, BP.JP

• Abstract

  In contrast to what it was usually believed in the last decades, many studies carried out in the last years have shown that the anions nitrate and nitrite are not simply inert biological products of nitric oxide (NO) oxidation. In fact, nitrates are secreted by salivary glands into saliva after their absortion in the gastrointestinal system, and nitrates are reduced to nitrites by oral ba…

  Protein nitrosylation in the antihypertensive mechanisms of treatment with sodium nitrite, BP.PD

(Only some records are available in English at this moment)