Silvia Maria Fátima Di Santi

• Abstract

  BackgroundEfforts have been made to establish sensitive diagnostic tools for malaria screening in blood banks in order to detect malaria asymptomatic carriers. Microscopy, the malaria reference test in Brazil, is time consuming and its sensitivity depends on microscopist experience. Although molecular tools are available, some aspects need to be considered for large-scale screening: accur…

  Still Searching for a Suitable Molecular Test to Detect Hidden Plasmodium Infection: A Proposal for Blood Donor Screening in Brazil, PUB.ART
• 64th Annual Meeting of the American Society of Tropical Medicina & Hygiene, AR.EXT

• Abstract

  Malaria transmitted by blood transfusion remains one of the infections that are most relevant to hemotherapy services, both in endemic and non endemic areas due to the large increase in the number of individuals moving globally. Data on the frequency of blood transfusion malaria show values ranging from less than 0.2 per million units of blood in non-endemic countries to 50 or more in are…

  Platform for malaria diagnosis applied to samples of blood donors from endemic and non-endemic Brazilian areas processed in pool: determination of the frequency of positivity using serological and molecular markers, AP.R

(Only some records are available in English at this moment)

• Abstract

  Malaria is an infectious disease that challenges the science and the control programs. In Brazil, most cases occur in the Amazon region, with 193,886 news cases in 2017, a worrying increase of 51% compared to 2016. In the Extra-Amazon Region, the impact of the disease is due to imported cases and to the occurrence of outbreaks. In 2017, from 445 reported cases, 86 were classified as autoc…

  Molecular detection of Plasmodium in areas of autochthonous malaria in the Atlantic Forest biome of the State of São Paulo - the role of asymptomatic infections in the maintenance of transmission, BP.MS

• Abstract

  In Brazil, in 2015, 142,562 cases of malaria were notified. P. vivax was responsible for 89.2% of cases, followed by P. falciparum and mixed infections, with 10.8%. P. malariae is a species with rare notification, which does not represent the epidemiological reality, since it can be diagnosed as P. vivax. The Extra-Amazon Region is not considered endemic for malaria, but is susceptible to…

  Molecular diagnosis for asymptomatic infections due to Plasmodium in the North Coast of São Paulo State, BP.IC

• Abstract

  Approximately 3.3 billion people live at risk of contracting malaria worldwide, with 219 million cases and 660,000 deaths in 2010. In 2011 were notified 267,000 cases of the disease in Brazil. Plasmodium falciparum requires prompt and effective treatment, due to its ability to evolve to severe cases and death. Artemisinin derivatives can reach high plasma levels quickly, reducing signific…

  Behavior of Plasmodium falciparum against first-line regimens for malaria: evaluation of in vitro sensitivity and dormancy mechanism of artemisinin combination therapies, BP.DR

(Only some records are available in English at this moment)