Abstract
Aldosterone induces endothelial dysfunction by inflammatory and pro-fibrotic-mechanisms-dependent. Nod-like receptors - NLR are cytoplasmic proteins, which recognize endogen molecules and pathogens. These receptors are expressed in cells from immune system, smooth muscle cells and in endothelium. Aldosterone activates NLRP3, member of NLRs family, in cells from immune system and in the va…