Abstract
Chronic treatment with NADPH oxidase inhibitors reduces blood pressure in SHR. As the main source of superoxide anion in the aorta, the activity of this enzyme is associated with decreased NO bioavailability and uncoupling of eNOS. Rats that developed cardiac hypertrophy had a higher myocardial expression of p22phox and p67phox subunits of NADPH oxidase. This study will test the hypothesi…