CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Biologist (UFPE '09 - Universidade Federal de Pernambuco). PhD in Genetics at the Universidade de São Paulo (USP), 2015. Researcher at the Human Genome and Stem-cell Research Center (HUG-CELL) in collaboration with the Brain Institute, Albert Einstein Hospital. Member of the American Society of Human Genetics. Research interests: population genomics, cell and molecular biology (genetics), functional genomics, biochemistry, bioinformatics. ORCID: https://orcid.org/0000-0002-9068-1713 (Source: Lattes Curriculum)
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APOE gene is consistently associated with risk of developing dementia, particularly Alzheimer's disease (AD), and e4 allele is the highest effect risk factor attributed to the most prevalent form of AD with multifactorial etiology. Recent studies showed that e4 contribution depends on global ancestry of the patient and local ancestry around the gene, with attenuated risk among Africans wh…
Variants in gene regions can have functional effects over its products, often with consequences to clinical phenotypes. Coding non-synonymous variants, to which amino acids are substituted, can impact protein structure and, as a consequence, its function. The analysis and assessment of the effects of the presence of simultaneous non-synonymous coding variants in cis configuration (across …
The APOE gene is identified as a major risk factor for late onset Alzheimer's disease and has three alleles, µ2, µ3 and µ4, related to two non-synonymous substitutions. The presence of the µ4 allele confers an increased risk for the disease in a dose dependent manner (odds ratio 12.9 for homozygous individuals and between 3.2 and 4.2 for heterozygous individuals). The most prevalent form …
Handedness, or hand dominance, is the unequal distribution of manual dexterity between hands. In human populations, in average, 90% of individuals are more skilled with their right hand, while to other animals this ratio is around 1:1. The brain cortex controls this feature in a lateralized or asymmetrical manner. Within the population level, it is possible to detect variability throughou…
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| 3 / 3 | Completed scholarships in Brazil |
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