Abstract
Our recent studies comparing two C57BL6 mice strains with or without deficiency of mitochondrial nicotinamide nucleotide transhydrogenase (NNT) revealed that the absence of NNT is associated with increased adiposity, hepatic steatosis, glucose intolerance and hyperinsulinemia (insulin resistance) and insulin hypersecretion. Furthermore, an increase of total insulin content in pancreatic i…